Brain Development and Microbiome Effect

The human gut host contains1014 bacterial organisms, which is an amount that exceeds the cells within the body. • Microbiota is the bacteria living both inside and on the human body (a community collectively known as, dwelling in the human microbiome), mostly are friendly and they outnumber the somatic and germ cells of the body by a factor of 10. • Specific to the human gut are the commensal microflora which enter into an important symbiotic association with the human host beginning with the colonization of the gastrointestinal (GI) tract by the bacteria within half an hour after delivery and continue to develop depending on many factors. This is developmental process begins at birth and continue through early development, and remains for life. • This developmental processing is actually active during vulnerable or sensitive developmental periods and thus it exerts influences that impact on the structure and function of organs (brain) that last throughout life. • However, although the colonization of microbiota is due to postnatal environmental factors and is also affected by genetics and it is consistent and is difficult to change after reaching the adult form. • It has a prenatal and postnatal effect on the developing of the infant brain. • The microbiota are essential to the proper development of the mucosal and systemic immune systems and in nutrient uptake and metabolism as important contributors in making the individual’s physiology and influence the function of the central nervous system (CNS) and behavior. • Of particular interest is the impact of the microbiota on the functional development of the infant (mammalian) brain. • The developing brain is susceptible to internal and external cues during its perinatal life, an important point when considering the association between common neurodevelopmental disorders (e.g. autism and schizophrenia) and microbial pathogen infections during this same period. Breast feeding and probiotics are now being recognized in the brain -gut axis interaction.